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Drug interactions are less of a problem with metformin. In a few cases, cimetidine administration resulted in increased plasma-metformin concentration. The renal clearance of metformin was reduced, competition for proximal tubular excretion was considered responsible.
Furosemide: Furosemide increases the metformin plasma and blood Cmax and area under the curve (AUC) without any significant change in metformin renal clearance.
Nifedipine: Co-administration of nifedipine increased plasma metformin Cmax and AUC by 20% and 9%, respectively and increased the amount excreted in the urine.
Nifedipine appears to enhance the absorption of metformin. Metformin had minimal effects on nifedipine.
